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2.4 Preparation and Handling. Each vial of TYGACIL should be reconstituted with 5.3 mL of 0.9% Sodium Chloride Injection, USP, 5% Dextrose Injection, USP, or Lactated Ringer's Injection, USP to achieve a concentration of 10 mg/mL of tigecycline. (Note: Each vial contains a 6% overage.

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Administration of intravenous tigecycline in pregnant rats and rabbits during period of organogenesis was associated with reduction in fetal weights and an increased incidence of skeletal anomalies (delays in bone ossification) at exposures of 5 and 1 times the human exposure at recommended clinical dose in rats and rabbits, respectively.

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TYGACIL and 3.0% (110/3646) of patients receiving comparator drugs. In a pooled analysis of these trials, based on a random effects model by trial weight, an adjusted risk difference of all-cause mortality was 0.6% (95% CI 0.1, 1.2) between TYGACIL and comparator-treated patients. The cause of this increase has not been established.

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sodium picosulfate/magnesium oxide/anhydrous citric acid. tigecycline decreases effects of sodium picosulfate/magnesium oxide/anhydrous citric acid by altering metabolism. Use Caution/Monitor. Coadministration with antibiotics decreases efficacy by altering colonic bacterial flora needed to convert sodium picosulfate to active drug.

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The most common side effects with Tygacil are mild to moderate nausea (feeling sick) and vomiting, seen in 20% and 14% of patients, respectively. For the full list of all side effects reported with Tygacil, see the package leaflet. Tygacil must not be used in people who are hypersensitive (allergic) to tigecycline or any of the other ingredients.

Dose

Tygacil termasuk dalam golongan obat keras, hanya bisa didapatkan dan digunakan berdasarkan resep Dokter. Berikut dosis dan aturan penggunaan Tygacil sesuai jenis infeksi: Dosis Tygacil yang direkomendasikan: Dewasa dosis awal 100 mg sebagai dosis tunggal, diikuti dengan dosis 50 mg tiap 12 jam selama 5-14 hari.

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Tygacil belongs to a group of drugs called glycycline antibiotics, which work by binding to bacteria and killing them. This medication comes in an injectable form to be given directly into the vein (IV) by a healthcare provider. Common side effects of Tygacil include nausea, vomiting, and stomach pain. Tygacil can cause dizziness.

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The recommended dosage regimen for TYGACIL is an initial dose of 100 mg, followed by 50 mg every 12 hours. Intravenous infusions of TYGACIL should be administered over approximately 30 to 60 minutes every 12 hours. The recommended duration of treatment with TYGACIL for complicated skin and skin structure infections or for complicated intra.

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Berikut adalah dosis tigecycline untuk orang dewasa yang dibagi berdasarkan kondisi yang akan ditangani: Dosis awal 100 mg pada hari pertama, diikuti dengan dosis lanjutan sebanyak 50 mg, melalui infus yang diberikan selama 30-60 menit, tiap 12 jam. Durasi pengobatan adalah 7-14 hari.

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TYGACIL is a tetracycline class antibacterial indicated in patients 18 years of age and older for: • Complicated skin and skin structure infections ()Complicated intra-abdominal infections ()Community-acquired bacterial pneumonia ()Limitations of Use: TYGACIL is not indicated for treatment of diabetic foot infection or hospital-acquired pneumonia, including ventilator-associated pneumonia ().

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TYGACIL may be initiated as empiric monotherapy before results of these tests are known. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Adult Dosage The recommended dosage regimen for TYGACIL is an initial dose of 100 mg, followed by 50 mg every 12 hours. Intravenous infusions of TYGACIL should be administered over

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1. NAME OF THE MEDICINAL PRODUCT. TYGACIL (TIGECYCLINE) INJECTION 50 MG. 2. QUALITATIVE AND QUANTITATIVE COMPOSITION. Tigecycline for injection is supplied in single-dose, 5 ml, Type 1 glass vials containing 50 mg lyophilized powder for infusion. Each vial contains 100 mg of lactose monohydrate. The pH is adjusted with hydrochloric acid, and if.

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This product information is intended only for residents of the United States. for Healthcare professionals: TYGACIL U.S. Physician Prescribing Information. TYGACIL U.S. Medical Information Page - clinical & safety information, ways to contact Pfizer Medical & other resources. TYGACIL® PremierPro U.S. Physician Prescribing Information.

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Tigecycline, sold under the brand name Tygacil, is a tetracycline antibiotic medication for a number of bacterial infections. It is a glycylcycline administered intravenously. It was developed in response to the growing rate of antibiotic resistant bacteria such as Staphylococcus aureus, Acinetobacter baumannii, and E. coli. As a tetracycline derivative antibiotic, its structural modifications.